The main objective of this guidance is to provide scientific advice on public health principles and considerations for infection and prevention control of COVID-19 in migrant and refugee reception and detention centres in the European Union and European Economic Area (EU/EEA) and the United Kingdom (UK). The target audience for this guidance includes national, regional and international policymakers, public health and healthcare planners, staff working in migrant/refugee reception and detention centres, health researchers, health professionals, and civil society organisations working with migrant populations.